She engaged in inter-species hanky-panky and people still call her great.

Amy: Do you know the story of Catherine the Great?

Penny: No.

Amy: She ruled Russia in the late 1700s, and one night when she was feeling particular randy

...she used an intricate system of pulleys to have intimate relations with a horse.

Penny: ...I'm sorry, but what does this have to do with me?

Amy: She engaged in inter-species hanky-panky and people still call her great.

I'm sure your reputation can survive you shagging a little Indian boy.

<The Big Bang Theory, s05ep10, The Skank Reflex Analysis>